Research

Mr Alex Day is an honorary clinical Associate Professor at University College London and has over 70 publications. Being research trained means he can offer his patients the latest treatments to give them the best surgical outcomes and customer service.

Image: ESCRS faculty and speakers at the ESCRS Academy during the 50th Jubilee Congress of Polish Ophthalmologists in Warsaw, Poland.

Alex Day is internationally recognised for his research in cataract and refractive surgery. He was ranked no.2 globally by The Ophthalmologist as a Rising Star in 2017.

Alex is an Honorary Associate Professor at UCL Institute of Ophthalmology, London. He has published over 70 papers in peer reviewed medical journals. He was responsible for the concept and formation of the group behind the Femtosecond laser Assisted Cataract Trial (FACT). This is a £1.5 million NIHR funded multicentre randomised controlled trial of femtosecond laser assisted cataract surgery (FLACS) vs conventional phacoemulsification cataract surgery (standard ultrasound cataract surgery).

Alex is an examiner for the Royal College of Ophthalmologists’ Certificate in Laser and Refractive Surgery. He was the lead author on the previous Royal College of Ophthalmologists National Ophthalmology Database publications on cataract surgery outcomes that provide national benchmarking standards for visual outcomes and complication rates. Alex is a lecturer on the Ulster University Postgraduate Diploma in Cataract and Refractive Surgery (PgDipCRS) course.

Alex is a member of many professional organisations including the UK and Ireland Society of Cataract and Refractive Surgeons (UKISCRS) and the European Society of Cataract and Refractive Surgery (ESCRS) and the American Society of Cataract and Refractive Surgery (ASCRS).

Publications

Lancet

Day AC, Findl O. Femtosecond laser-assisted vs conventional cataract surgery. Lancet. 2020 Jan 18;395(10219):170-171. doi: 10.1016/S0140-6736(19)32622-4.

Ophthalmology

Day AC, Burr JM, Bennett K, Bunce C, Doré CJ, Rubin GS, Nanavaty MA, Balaggan KS, Wilkins MR; FACT group. Femtosecond Laser-Assisted Cataract Surgery Versus Phacoemulsification Cataract Surgery (FACT): A Randomized Noninferiority Trial. Ophthalmology. 2020 Mar 3:S0161-6420(20)30214-1. doi: 10.1016/j.ophtha.2020.02.028

Day AC, Donachie PHJ, Sparrow JM, et al. United Kingdom National Ophthalmology Database Study of Cataract Surgery: Report 3: Pseudophakic Retinal Detachment. Ophthalmology 2016;123:1711–1715.

Lee AY, Day AC, Egan C, et al. Previous Intravitreal Therapy Is Associated with Increased Risk of Posterior Capsule Rupture during Cataract Surgery. Ophthalmology 2016;123:1252–1256.

Day AC, Ayliffe W, Bland M. Deep Anterior Lamellar Keratoplasty. Ophthalmology 2008. 115(10), 1847-1848

Nature Genetics

Khor CC, Do T, Jia H, et al. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics 2016;48:556–562.

Journal of Cataract and Refractive Surgery

Day AC, Stevens JD. Predictors of femtosecond laser intrastromal astigmatic keratotomy efficacy for astigmatism management in cataract surgery. J Cataract Refract Surg 2016;42:251–257.

Day AC, Lau NM, Stevens JD. Nonpenetrating femtosecond laser intrastromal astigmatic keratotomy in eyes having cataract surgery. J Cataract Refract Surg 2016;42:102–109.

Day AC, Gartry DS, Maurino V, Allan BD, Stevens JD. Efficacy of  anterior  capsulotomy creation in femtosecond laser-assisted cataract surgery. J Cataract Refract Surg. 2014;40(12):2031-4.

Day AC, MacLaren RE, Bunce C, Stevens JD, Foster PJ. Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos. J Cataract Refract Surg. 2013 Jan;39(1):87-96.

Day AC, MacLaren RE, Bunce C, Stevens JD, Foster PJ. Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos. J Cataract Refract Surg. 2013 Jan;39(1):87-96.

Day AC, Maclaren RE, Bunce C, Stevens JD, Foster PJ. Reply: Cataract surgery and microphthalmic eyes. J Cataract Refract Surg. 2013 May;39(5):818-9.

Reinstein DZ, Pradhan KR, Carp GI, Archer TJ, Day AC, Sekundo W, Dhungana P. Small Incision Lenticule Extraction for Hyperopia: 3-Month Refractive and Visual Outcomes. J Refract Surg. 2019 1;35(1):24-30

Reinstein DZ, Carp GI, Archer TJ, Day AC, Vida RS. Outcomes for Hyperopic LASIK With the MEL 90® Excimer Laser. J Refract Surg. 2018 1;34(12):799-808.

Day AC, Stevens JD. Stability of Keratometric Astigmatism After Non-penetrating Femtosecond Laser Intrastromal Astigmatic Keratotomy Performed During Laser Cataract Surgery. J Refract Surg 2016;32:152–155.

Day AC, Angunawela RI, Allan BDS. Blow-back technique for confirmation of peripheral iridectomy patency, Journal of Cataract & Refractive Surgery: November 2008, 34(11). 1832-1833

BMJ Open

Hoffman J, Spencer F, Ezra D, Day AC. Changes in UK ophthalmology surgical training: analysis of cumulative surgical experience 2009-2015. BMJ Open. 2017 Oct 6;7(10):e018526

Day AC, Dhallu SK, Maurino V, Wilkins MR. Initial experience using a femtosecond laser cataract surgery system at a UK National Health Service cataract surgery day care centre. BMJ Open 2016;6:e012078.

Day AC, Burr JM, Bunce C, Dore CJ, Sylvestre Y, Wormald RPL, Round J, McCudden V, Rubin G, Wilkins MR on behalf of the FACT Group. Randomised, Single Masked Non-  Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract: The FACT trial protocol. BMJ Open. 2015 Nov 27;5(11):e010381

Day AC, Khawaja AP, Peto T, Hayat S, Luben R, Broadway DC, Khaw KT, Foster PJ. The small eye phenotype in the EPIC-Norfolk eye study: prevalence and visual impairment in microphthalmos and nanophthalmos. BMJ Open. 2013 Jul 24;3(7)

European Journal of Ophthalmology

Roberts HW, Day AC, O’Brart DP. Femtosecond laser-assisted cataract surgery: A review. Eur J Ophthalmol. Eur J Ophthalmol. 2020 May;30(3):417-429. doi: 10.1177/1120672119893291. Epub 2019 Dec 4.

Eye

Johnston RL, Day AC, Donachie PHJ, Sparrow JM. The Royal College of Ophthalmologists’ National Ophthalmology Database study of cataract surgery: report 4, equity of access to cataract surgery. Eye (Lond). 2020 Mar;34(3):530-536. doi: 10.1038/s41433-019-0524-x. Epub 2019 Jul 29.

Day AC, Wormald R, Coronini-Cronberg S, et al. The Royal College of Ophthalmologists’ Cataract Surgery Commissioning Guidance: executive summary. Eye 2016;30:498–502.

Day AC, Donachie PHJ, Sparrow JM, Johnston RL. The Royal College of Ophthalmologists’ National Ophthalmology Database Study of Cataract Surgery: Report 2, Relationships of Axial Length with Ocular Co-Pathology, Pre-operative Visual Acuity and Posterior Capsule Rupture. Eye. 2015 Dec;29(12):1528-37.

Day AC, Donachie PHJ, Sparrow JM, Johnston RL. The Royal College of Ophthalmologists’ National Ophthalmology Database Study of Cataract Surgery: Report 1, Visual Outcomes and Complications. Eye, 2015 Apr;29(4):552-60

Day A, Foster, P. Response to: Idiopathic uveal effusion syndrome causing unilateral acute angle closure in a pseudophakic patient. Eye 251660 (2011).

Day A, Seward, H. Delayed radial keratotomy dehiscence following uneventful phacoemulsification cataract surgery. Eye, 2007. 21, 886–887

Day A, Ramkissoon Y, George S, Corbett MC. Traumatic dislocation of an iris-fixated phakic intraocular lens. Eye. 2007. 21, 121–122.

Day A, Davies N. Reply to T Rimmer and W Wyke: Quicker painless diabetic laser. Eye. 2007. 21, 140–141.

Day A, Ramkissoon, Y, George, S, Corbett MC. Don’t forget Gonococcus!. Eye. 2006. 20, 1400–1402.

British Journal of Ophthalmology

Day AC, Dhariwal M, Keith MS, Ender F, Perez Vives C, Miglio C, Zou L, Anderson DF. Distribution of preoperative and postoperative astigmatism in a large population of patients undergoing cataract surgery in the UK. Br J Ophthalmol. 2019 Jul;103(7):993-1000

Day AC, Cooper D, Burr J, Foster PJ, Friedman DS, Gazzard G, Che-Hamzah J, Aung T, Ramsay CR, Azuara-Blanco A. Clear lens extraction for the management of primary angle closure glaucoma: surgical technique and refractive outcomes in the EAGLE cohort. Br J Ophthalmol. 2018. 102(12):1658-1662

Day AC, Cooper D, Burr J, Foster PJ, Friedman DS, Gazzard G, Che-Hamzah J, Aung T, Ramsay CR, Azuara-Blanco A. Clear lens extraction for the management of primary angle closure glaucoma: surgical technique and refractive outcomes in the EAGLE cohort. Br J Ophthalmol. 2018 Feb

Chua PY, Day AC, Lai KL, Hall N, Tan LL, Khan K, Lim   LT, Foot B, Foster PJ, Azuara-Blanco A. The incidence of acute angle closure in Scotland: a prospective surveillance study. Br J Ophthalmol. 2017 Aug 9. pii: bjophthalmol-2017-310725.

Day AC, Luben R, Khawaja AP, Low S, Hayat S, Dalzell N, Wareham NJ, Khaw KT, Foster PJ. Genotype-phenotype analysis of SNPs associated with primary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular biometry in the EPIC-Norfolk Eye Study. Br J Ophthalmol. 2013 Jun;97(6):704-7

Day AC, Garway-Heath DF, Broadway DC, Jiang Y, Hayat S, Dalzell N, Khaw KT, Foster PJ. Spectral domain optical coherence tomography imaging of the aqueous outflow structures in normal participants of the EPIC-Norfolk Eye Study. Br J Ophthalmol. 2013 Feb;97(2):189-95.

Day AC, Baio G, Gazzard G, Bunce C, Azuara-Blanco A, Munoz B, Friedman DS, Foster PJ. The prevalence of primary angle closure glaucoma in European derived populations: a systematic review. Br J Ophthalmol. 2012. 96(9): 1162-7.

de Silva DJ, Day AC, Bunce C, Gazzard G, Foster PJ. Randomised trial of sequential pretreatment for Nd:YAG laser iridotomy in dark irides. Br J Ophthalmol. 2012. 96(2): 263-6

Day AC. Foster PJ. How large should an iridotomy be? Br J Ophthalmol. 2011. 95: 747-748.

Day AC, Foster PJ. Increases in rates of both laser peripheral iridotomy and phacoemulsification have accompanied a fall in acute angle closure rates in the UK. Br J Ophthalmol .2011 Sep;95(9):1339-40

American Journal of Ophthalmology

Gadhvi KA, Romano V, Fernández-Vega Cueto L, Aiello F, Day AC, Allan BD. Deep anterior lamellar keratoplasty for keratoconus: multi-surgeon results. Am J Ophthalmol. 2019 May;201:54-62

PLoS One

Pontikos N, Chua S, Foster PJ, Tuft SJ. Day AC. Frequency and distribution of corneal astigmatism and keratometry features in adult life: Methodology and findings of the UK Biobank study. PLoS One. 2019 Sep 19;14(9):e0218144

IOVS (Investigative Ophthalmology & Visual Science)

Day AC, Machin D, Aung T, Gazzard G, Husain R, Chew PT, Khaw PT, Seah SK, Foster PJ. Central corneal thickness and glaucoma in East Asian people. IOVS. 2011. 52(11): 8407-12

Clinical and Experimental Ophthalmology

Day AC, Foster PJ, Stevens JD. Accuracy of intraocular lens power calculations in eyes with axial length <22.00mm. Clin Experiment Ophthalmol. 2012 Dec;40(9):855-62.

Muthiah MN, Day AC, Singh RP, Malik N, Adams ME, Olver JM. Frontal sinus pneumocoele: a rare cause of orbital emphysema. Clin Exp Ophthalmol. 2007;35(8):772-773.

BMJ Case Reports

Day AC, Nolan W, Malik A, Pilocarpine induced acute angle closure. BMJ Case Reports 2012; bcr0120125694.

Documenta Ophthalmologica

Day AC, Rotsos, T., Holder, G.E. et al. Electrodiagnostic and two-wavelength fundus autofluorescence imaging investigations in acute idiopathic maculopathy. Doc Ophthalmol 121155–160 (2010).

Molecular Vision

Mukhopadhyay R, Sergouniotis PI, Mackay DS, Day AC, Wright G, Devery S, Leroy BP, Robson AG, Holder GE, Li Z, Webster AR. A detailed phenotypic assessment of individuals affected by MFRP-related oculopathy. Mol Vis. 2010 Mar 26;16:540-8.

Neuro-Ophthalmology

Malik NM, Day AC, Clifton A, Wren D (2007) Weber’s Syndrome as the Presenting Sign of Multiple Sclerosis, Neuro-Ophthalmology, 31:1, 15-17.

Acta Ophthalmologica Scandinavica

Kalev‐Landoy M, Day AC, Cordeiro MF, Migdal, C, Optical coherence tomography in anterior segment imaging. Acta Ophthalmologica Scandinavica, 2007. 85: 427-430.

British Journal of Hospital Medicine

Day A, Malik N. Giant cell arteritis presenting as painful third nerve palsy. British Journal of Hospital Medicine. 2006;67(7):383.

The Journal of Emergency Medicine

Shah AN, Day AC, Healy VC, Olver JM. Eyelid Necrotizing Fasciitis: What Were the Early Signs? The Journal of Emergency Medicine. 2013, 44(2) 349-351.

Day A, Carp G. Response to Thyagarajan et al’s audit: “An audit of corneal abrasion management following the introduction of local guidelines in an accident and emergency department.” Emergency Medicine Journal 2006;23:959.